Cisdiamminedichloroplatinum

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Web目的应用免疫组化方法观察豚鼠内耳S-100蛋白的表达。方法选用健康,Preyer’s反射正常豚鼠8只,4%多聚甲醛活体灌注后耳蜗冰冻切片,采取SP免疫组化方法进行S-100蛋白染色。结果耳蜗Corti’s器内外毛细胞,Deiter及Hensen细胞呈阳性表达,基底膜下细胞未着色,螺旋缘齿间细胞,螺旋神经节细胞间纤维,螺旋韧带及 ... WebDec 3, 1979 · [Cis-diamminedichloroplatinum(II). A new antineoplastic agent derived from the group of heavy metal complexes (author's transl)] Platinum coordination complexes represent a new class of antineoplastic agents among which only cis-diamminedichloroplatinum(II) (cis-DDP) has undergone extensive clinical trials.

Abstract - American Association for Cancer Research

WebSpectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Spectrum of cis-diamminedichloroplatinum (II)-induced mutations in a shuttle vector propagated in human cells Authors G J Bubley 1 , B P Ashburner , B A Teicher Affiliation WebCis-diamminedichloroplatinum (II)-induced acute renal failure in the rat. Correlation of structural and functional alterations T. W. Jones, S. Chopra, J. S. Kaufman, W. … china\u0027s strategy in the south china sea

Cisplatin (cis-diamminedichloroplatinum II) - ScienceDirect

WebThe thioredoxin (TRX) system, composed of nicotinamide adenine dinucleotide phosphate (reduced form), TRX, and TRX reductase (TRXR), has multiple biologic functions via thiol-mediated redox control. In this study, we investigated the relationship between intracellular TRXR levels and cellular sensitivity to cis-diamminedichloroplatinum (II) (CDDP). WebJun 1, 1973 · cis -Diamminedichloroplatinum (II) is the first of a group of platinum coordination complexes with antineoplastic activity to be studied in humans. This Phase I investigation characterizes the toxicity and pharmacological disposition of … WebWe demonstrated previously that the effect of cis-diamminedichloroplatinum(II) (cisplatin) against pancreatic cancer was substantially enhanced by the addition to the … china\u0027s support to ru

Effects of cis-Diamminedichloroplatinum (NSC 119875) on Murine …

Possible involvement of thioredoxin reductase as well as …

WebA comparative study was performed with a variety of human cell lines on the effects of treatments with cis-diamminedichloroplatinum (II) (cisplatin) on cell survival and the induction of unscheduled DNA synthesis. WebCisplatin (cisplatinum, cis-diamminedichloroplatinum II, CDDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA adducts in tumor cells. Cisplatin activates ferroptosis and induces autophagy. Solutions are best fresh-prepared. Catalog No. NC0564900 $86.10 / Each of 1 Qty Check Availability Add to cart china\u0027s supply chainWebCisplatin (cis-diamminedichloroplatinum) is an alkylating agent and a subset of platinum (II) analogs. It acts by producing an immensely reactive moiety that facilitates the cross … china\u0027s success in poverty alleviation

"WebMay 15, 2015 · The interest in gold(III) as anticancer agent is a result of the current significance of the anticancer cisplatin, cis-diamminedichloroplatinum(II), [PtCl 2 (NH 3) 2] . Although cisplatin has been used for a long time for the treatment of different types of cancer there are several limitations and drawbacks. Gold(III) compounds provided ... " - Cisdiamminedichloroplatinum

Cisdiamminedichloroplatinum

Effect of Co-Treatment with Static Magnetic Fieldand Cis ...

Web1-β-D-Arabinofuranosylcytosine (ara-C) and hydroxyurea (HU) were investigated as possible inhibitors for the repair of cis-diamminedichloroplatinum(II) (DDP)-induced DNA damage. HU and ara-C were chosen for their known ability to … WebNov 1, 1983 · cis -Platinum, bleomycin, 5-fluorouracil, and cyclophosphamide were administered to rodent and canine models of osmotic blood-brain barrier modification to evaluate the relationship between tissue drug concentration in brain and the physiological and neuropathological effects of the drug.

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WebJul 4, 1995 · The combination of cis-diamminedichloroplatinum(II) (CDDP) and 7-ethyl-10-[4-(I -piperidino)-I -piperidino]carbonyloxycamptothecin (CPT-I I), a topoisomerase-l inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To elucidate the mechanism of the … WebA docetaxel-resistant prostate cell line (PC3DR2) was subsequently established using the same method (9); resistance-associated genes in this cell line were examined in the present study through DNA microarray, western blot analysis and reverse transcription-quantitative polymerase chain reaction (RT-qPCR).

シスプラチン（英語: cisplatin、略称:CDDP）は、白金錯体に分類される抗悪性腫瘍剤（抗がん剤）。シスプラチンの「シス」は、立体化学の用語のシスに由来する。錯体の中心金属は白金、配位子はアンミンと塩化物イオンであり、物質名はシス-ジアミンジクロロ白金(II)（cis-diamminedichloro-platinum(II)、cis-[PtCl2(NH3)2]）である。なお、日光によって分解されるため、直射日光を避 … WebCisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cisplatin (cis-diamminedichloroplatinum II) Cancer Treat Rev. 1979 Mar;6(1):17-39. doi: …

WebThe records of 15 sequential cases of transitional cell carcinoma of the urinary bladder or urethra in dogs were examined to determine the results of treatment with cisplatin … Webcis-Diamminedichloroplatinum (II) induced distortion in a double-helical DNA fragment jeroen den hartog 1984, Journal of The American Chemical Society Download Free PDF Related Papers Journal of the … Mechanism of two-electron oxidation of deoxyguanosine 5'-monophosphate by a platinum (IV) complex 2004 • Amanda Hakemian Download Free …

WebJun 1, 1975 · Summary. The effects of cis -diamminedichloroplatinum (NSC 119875) on murine and human hemopoietic precursor cells were studied in culture. When murine …

Webtrans-Platinum(II) diamminedichloride Cl2H6N2Pt+2 CID 441203 - structure, chemical names, physical and chemical properties, classification, patents, literature ... china\u0027s sweatshopsWebCisplatin Cl2H6N2Pt CID 5460033 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ... china\u0027s sui wenjing and han congWebMar 1, 1979 · 1. Cisplatin is a co-ordination complex of a central platinum atom, two chlordies and two ammonia molecules in the “ cis ” position. 2. A prime mechanism of … china\\u0027s support for russiaWebAbstract. Fifty patients with disseminated testicular cancer were treated with a three-drug combination consisting of cis-diamminedichloroplatinum, vinblastine, and bleomycin. … granbury swimming poolWebcis-Diamminedichloroplatinum(II): effects of a representative metal coordination complex on mammalian cells Pharmacol Ther. 1984;25(3):297-326.doi: 10.1016/0163-7258(84)90003-2. Author E B Douple PMID: 6542679 DOI: 10.1016/0163-7258(84)90003-2 No abstract available Publication types china\u0027s support for russiaWebSep 1, 1990 · The specific drug combination and experimental growth system for this introductory application was that of 1-β- d -arabinofuranosylcytosine (ara-C) and cisplatin with simultaneous drug exposure (1, 3, 6, 12, or 48 h) against L1210 leukemia in vitro. granbury sushiWebA regression rate of 12% (4/33) among patients with advanced upper aerodigestive carcinomas who received an intravenous regimen of cis‐diamminedichloroplatinum, … china\\u0027s swift system