Dynamics of gene expression in single

Author: ucel

August undefined, 2024

WebFeb 9, 2024 · Single Cell Dynamics Group is interested in understanding why genetically identical cells respond heterogenous to environmental stimuli. Recent research suggests that in diseases, such as cancer or the process of aging, expression variability increases in tissue. Determining the factors and mechanisms that regulate this variability will help us ... WebMay 13, 2024 · Single cell RNA-sequencing (scRNA-seq) of human and animal tissues has produced unprecedented insight into gene expression changes underlying development …

Technique to measure the expression dynamics of each …

WebNov 18, 2024 · Despite advances in single-cell analysis, dynamics and topology of the cell cycle in high-dimensional gene expression space remain largely unknown. We developed a linear analysis of transcriptome data which reveals that cells move along a planar circular trajectory in transcriptome space during the cycle. WebNov 18, 2024 · Abstract. To decipher cell state transitions from single-cell transcriptomes it is crucial to quantify weak expression of lineage-determining factors, which requires computational methods that are ... chirping of birds sound

Single-cell transcriptomics reveals gene expression dynamics of …

WebApr 8, 2024 · an inherent feature of gene expression. Single-cell studies. have shown that stochasticity in gene product le vels is. ... the altered nonlinear degradation, the moment … Web7 hours ago · Introductionβ-Mannanase is a plant cell wall remodeling enzyme involved in the breakdown of hemicellulose and plays an important role in growth by hydrolyzing the mannan-like polysaccharide, but its function in adaptation to salt stress has been less studied.MethodsBased on cloned the mannanase (MAN) gene from Mirabilis jalapa L., … WebThe approaches and results presented here, along with the copublished paper by Wagner et al., establish the first steps toward a data-driven dissection of developmental dynamics … chirp.in.gov

SINGLE-CELL ANALYSIS The dynamics of gene …

Dynamic gene expression and growth underlie cell-to-cell …

WebOct 1, 2011 · Single-Cell Gene Expression. (a) Dynamics of the prolactin promoter in rat pituitary cells observed by measuring the activity of a luciferase reporter ... It is the first study to interrogate gene expression dynamics on a scale that allowed comparison across eukaryotic genes, leading to the conclusion that kinetic signatures were highly gene ... WebAug 26, 2024 · Nongenetic heterogeneity, or gene expression stochasticity, is an important source of variability in biological systems. With the advent and improvement of single molecule resolution technologies, it has been shown that transcription dynamics and resultant transcript number fluctuations generate significant cell-to-cell variability that has … graphing emdrWebWe focused on stress-response genes in Escherichia coli to study the dynamics of expression and growth in single cells. Genes involved in adaptation to stress are … chirping of birds

"WebMar 28, 2024 · 1 1 RESEARCH ARTICLE 2 3 Dynamics of Gene Expression in Single Root Cells of A. thaliana 4 5 6 Ken Jean-Baptiste1, José L. McFaline-Figueroa1, Cristina … " - Dynamics of gene expression in single

Dynamics of gene expression in single

What do expression dynamics tell us about the mechanism of ...

WebJan 10, 2014 · To investigate allele-specific gene expression at single-cell resolution, we isolated 269 individual cells dissociated from in vivo F1 embryos (CAST/EiJ × C57BL/6J, hereafter abbreviated as CAST and C57, respectively) from oocyte to blastocyst stages of mouse preimplantation development (PD) ().We generated transcriptome profiles with … WebMar 12, 2024 · Dissimilarity matrix and local alignment between expression dynamics of a single gene module along LPS (left to right) and PAM (top to bottom) trajectories under similarity threshold of 0.25 of ...

Did you know?

Web7 hours ago · The upregulated expression gene, the response to dehydration 29A (AtRD29A), regarded as an indicator ... Lateral root formation at different developmental …

WebApr 14, 2024 · Sci-fate characterizes the dynamics of gene expression in single cells. Gene expression programs change over time, differentiation and development, and in response to stimuli. However, … WebGene expression programs change over time, differentiation and development, and in response to stimuli. However, nearly all techniques for profiling gene expression in …

WebApr 14, 2024 · The determination of the gene clusters revealed the correspondence between RNA kinetics and gene functions. This is indeed a remarkable and … WebAug 15, 2008 · Here, we are interested in the dynamics of such a switching process on the single cell level. We study these dynamics in the context of the arabinose utilization (ara) system of E. coli (11), another well-characterized bistable system (see Fig. 1).In this case, arabinose is imported by the high-affinity low-capacity transporter AraFGH and the low …

WebAug 3, 2024 · f, Gene expression dynamics resolved along latent time shows a clear cascade of transcription in the top 300 likelihood-ranked genes. g , Putative driver genes are identified by high likelihoods.

WebMay 13, 2024 · Dynamics of Gene Expression in Single Root Cells of Arabidopsis thaliana Abstract. Single cell RNA sequencing can yield … graphing e functionsWebApr 6, 2024 · Gene expression is the process by which cells produce proteins from information stored in DNA. Due to the small number of molecules involved in this process and their short lifetimes, random fluctuations or noise in protein levels are an inherent feature of gene expression. Single-cell studies have shown that stochasticity in gene … graphing end behaviorWeb2065. RNA-binding proteins. Professor James Eberwine describes the primary functions of RNA-binding proteins, which include regulating tRNAs, degrading RNAs, synthesizing … graphing eigenvectorsWebHowever, nearly all techniques for profiling gene expression in single cells do not directly capture transcriptional dynamics. In the present study, we present a method for combined single-cell combinatorial indexing and … chirp.in.gov log inWebApr 14, 2024 · Gene expression is a dynamic process on multiple scales, e.g. the cell cycle, response to stimuli, normal differentiation and development, etc. However, nearly all techniques for profiling gene expression in single cells fail to directly capture these temporal dynamics, which limits the scope of biology that can be effectively investigated. graphing easter bunny with eggWebMay 11, 2024 · By modelling gene expression as a Gaussian process, two competing models of single cell dynamics were proposed. An OU model describes random aperiodic fluctuations, but in contrast to white noise the fluctuations are correlated over time, and this may form a more appropriate model of non-oscillating single cells for statistical testing. chirping orchardsWebFeb 21, 2024 · In the study described here, we used single-cell RNA sequencing (scRNA-seq) to study gene expression dynamics in human fetal kidney development. Analysis of a fetal kidney from week 16 (w16) … graphing enzyme activity