WebNov 17, 2016 · Method Pitavastatin and atorvastatin PBPK models were developed using in vitro and human pharmacokinetic data in a population-based PBPK software (SimCYP®) … WebPitavastatin is in a class of medications called HMG-CoA reductase inhibitors (statins). It works by slowing the production of cholesterol in the body to decrease the amount of …
National Center for Biotechnology Information
WebNov 20, 2009 · Resulting PBPK simulations using those in vitro data were compared for plasma (human and rat) and bile (rat) concentration-time profiles following i.v. bolus administration of valsartan. An uncertainty analysis indicated that the scaled in vitro uptake clearance had to be adjusted with an additional empirical scaling factor of 5 to match the ... WebAug 3, 2024 · Briefly, minimal PBPK distribution models were used for both CYP2C8 substrates rosiglitazone and pioglitazone assuming rapid-equilibrium between blood and … pyosmium install
Prediction of pharmacokinetic profile of valsartan in human based …
WebSep 1, 2005 · Pitavastatin, a novel potent 3-hydroxymethylglutaryl coenzyme A reductase inhibitor, is distributed selectively to the liver and excreted into bile in unchanged form in … Webpitavastatin and its lactone form seemed to contribute to its long biological half-life and high bioavailability [7]. In the experimental animals, pitavastatin was distributed se-lectively to the liver, a target organ of statin action [8]. The bioavailability of rosuvastatin was about 20% and more than 80% of the drug was excreted into bile un- WebNov 24, 2024 · PBPK modeling may enable an optimized drug administration strategy for each individual patient by reflecting all of the characteristics such as the patient's ... (2024) Physiologically Based Pharmacokinetic (PBPK) modeling of pitavastatin and atorvastatin to predict Drug-Drug Interactions (DDIs). Eur J Drug Metab Pharmacokinet 42(4):689–705 ... pyoskin yt