Pttg1 and p53
WebApr 20, 2006 · To this end, we examined the effect of PTTG1 depletion on endogenous levels of p53 and p21. p21 is one of many genes to be induced by p53 and functions as a cyclin-dependent kinase inhibitor, which induces in cell-cycle arrest at G1 phase. 34 p53 level was not markedly affected by PTTG1 depletion, but p21 level was increased in a viral … WebMar 21, 2024 · Pituitary tumor-transforming gene 1 protein (PTTG1_HUMAN) PTTG1 protein (Q2VPE7_HUMAN) cDNA, FLJ92498, Homo sapiens pituitary tumor-transforming 1 (PTTG1), mRNA (Q6IAL9_HUMAN) ... Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by …
Pttg1 and p53
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WebMar 12, 2007 · For example, PTTG1 may bind to p53 and inhibit p21 transactivation (Bernal et al., 2002) which facilitates Rb phosphorylation, enabling the G1/S transition. c-Myc, induced by PTTG1, may in turn ... WebJun 21, 2024 · In addition, the existence of a complex network among p53 family members (p63 and p73) and their interactions with other factors that promote thyroid cancer progression has been well documented. ... The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology 2014, 155, 1222–1234. [Google …
WebJul 16, 2010 · Significantly, the PTTG1-induced senescence is p53-dependent and telomerase-independent, which is distinctively different from that of replicative senescence. The mechanism of PTTG1-induced senescence was also analyzed. Consistent with its role in regulating sister-chromatid separation, overexpression of PTTG1 inhibited the … WebSep 26, 2024 · pituitary tumor-transforming gene 1 protein-interacting protein, PTTG-binding factor, pituitary tumor-transforming gene protein-binding factor GeneRIFs: Gene References Into Functions protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are …
WebJul 24, 2024 · PTTG1 may also block p53 and regulate DNA repair mechanisms and apoptosis (Hornig et al., 2002). Our group has assessed a cohort of HTLV-1 asymptomatic carriers with the goal of finding clinical and molecular aspects related to ATL progression ( Sanabani et al., 2012 ; Pessoa et al., 2014 ; de Souza et al., 2024 ). WebOct 6, 2015 · Notably, some of the genes found to strongly correlate with PTTG1 expression in this study, including CDK1, CCNB1, CCNB2 and BIRC5 are known to be inhibited downstream of p53 [68–70]; p53-mediated regulation of gene expression down stream of PTTG1 could be a focus of future studies. However, we found no correlation between …
WebOct 6, 2015 · In our hands, p53 transcriptionally activated the expression of these miRNAs in pituitary tumor cells. Finally, we found that PTTG1 could inhibit p53 transcriptional activity to the four miRNAs. These data indicate the existence of a feedback loop between PTTG1 targeting miRNAs, PTTG1 and p53 that promotes pituitary tumorigenesis.
WebJul 8, 2004 · PTTG upregulates expression of p53 in HEK293 and MCF-7 cells. To determine the relationship between PTTG and p53, we first determined the effect of overexpression of PTTG on p53 expression. For this purpose, we used three different cell lines. Two of these HEK293, which is a human embryonic kidney cell line, and MCF-7, which is a human … grimsby beach studyWebPTTG1 . directly caused apoptosis in colorectal car - cinoma HCT116 cells. 15. Overexpression of PTTG1 will induce aneuploidy, which in turn causes apopto-sis. 13. Both p53 and PTTG1 are associated with cell cycle regulation, tumor develop-ment, DNA damage repair and apoptosis. Overexpression of PTTG1 inhibits the activation of separase, in ... fifty fifty mandaluyongWebJul 16, 2010 · To gain insight into the molecular basis of PTTG1-induced growth arrest and senescence in normal fibroblasts, we examined the expression pattern of several key cell cycle regulators that are involved in senescence using immunoblotting analysis.In IMR90 cells, PTTG1 overexpression consistently induced p53 expression and inhibited Rb protein … fifty fifty meda byron bayfifty fifty lyrics zappaWebObjective To analyze the expression of pituitary tumor transforming gene 1 (PTTG1) in hepatocellular carcinoma (HCC) and its clinical prognostic implication. ... p53 signaling pathway and human T-lymphotropic virus (HTLV) infection. PTTG1 and its co-expressed genes were mutated to some extent in HCC, and significantly shortened OS and DFS in ... fifty fifty meaningWebAug 17, 2011 · Cell lines and reagents. HCT116 is a human colon carcinoma cell line, expressing wild-type p53 and PTTG1 genes, and HCT116 p53 −/− and HCT116 PTTG1 −/− cell lines were derived using homologous recombination to knock out p53 or PTTG1 respectively , .Cells were cultured in McCoy's 5A medium containing 15% FBS. grimsby beachWebAug 18, 2024 · It should be noted that the PTTG family interacts with p53. For example, PTTG1 is thought to influence p53 activity by blocking p53 binding to DNA . Moreover, Méndez-Vidal et al. indicated that PTTG2 silencing results in increased levels of p53 protein . Suppressor p53 serves an important role in the cellular homeostasis maintenance . grimsby bbc sport